A Novel Method of Characterizing Seizure Onset Using Dynamic Response to Direct Electrical Stimulation
Abstract number :
1.526
Submission category :
3. Neurophysiology / 3E. Brain Stimulation
Year :
2025
Submission ID :
1279
Source :
www.aesnet.org
Presentation date :
12/6/2025 12:00:00 AM
Published date :
Authors :
Presenting Author: Patrick Davis, MD PhD – Boston Children's Hospital
Samuel Tomlinson, MD – Hospital of the University of Pennsylvannia
Caren Armstrong, MD PhD – UC Davis
Jurriaan Peters, MD PhD – Boston Children's Hospital
Benjamin Kennedy, MD – Children's Hospital of Philadelphia
Eric Marsh, MD, PhD – Children’s Hospital of Philadelphia; Perelman School of Medicine at the University of Pennsylvania
Rationale: Seizure onset - the abrupt, apparently stochastic transition from interictal to ictal network states - remains a core mystery of epilepsy. Understanding this transition is essential for the development of more effective therapies. To date, most analyses of seizure onset rely on descriptors of passively recorded network variables. Conversely, analysis of evoked responses to direct electrical stimulation (cortico-cortico evoked potentials, “CCEPs”) permits more direct interrogation of epilepsy networks, but thus far has only been applied to the interictal state. Therefore, in order to better understand the interictal-ictal transition, we analyzed CCEP dynamics preceding, during, and following onset of seizures that were triggered by direct cortical stimulation.
Methods: We leveraged a unique dataset of pediatric epilepsy patients who received systematic low-frequency (< 2Hz)
Neurophysiology