Acquired Hippocampal Damage during Simple Partial Status Epilepticus in Elderly
Abstract number :
1.193
Submission category :
Year :
2001
Submission ID :
2109
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
C. Adam, MD, PhD, Neurology, La Salpetriere, Paris, France, Metropolitan; C. Adam, MD, Neurology, Intercommunal, Villeneuve Saint Georges, France, Metropolitan; S. Dupont, MD, Neurology, La Salpetriere, Paris, France, Metropolitan; S. Clemenceau, MD, Neur
RATIONALE: Hippocampal Sclerosis (HS) is most of time associated with early prolonged febrile convulsions. MRI studies have shown that some other types of convulsive events may also be followed by hippocampal structural abnormalities.
METHODS: A 63-year-old man presented a simple partial Status Epilepticus (spSE) expressing by a permanent amnesic state during 15 days. His epilepsy was of recent discovery and without any pertinent antecedent. 4 MRI studies were done: 6 months before the spSE (showing a right hippocampal atrophy), during the spSE (day 11), after its resolution (day 42) and one year later.
RESULTS: The EEGs and the SPECT localized the ictal activity to the two temporal lobes, predominantly on the left side. The left hippocampal formation was swollen and hyperintense (day 11) and became progressively atrophic (day 42 and one year). The right hippocampus, originally atrophied, became slightly smaller one year later. The clinical outcome was poor one year later with a persistent anterograde amnesia.
CONCLUSIONS: Seizure-induced hippocampal insults are not always the consequence of tonic-clonic epileptic events. Subtle repetitive simple partial seizures forming a spSE may also lead to acute and, subsequently chronic, hippocampal damage.