Abstracts

Rationale: The mechanism of action of lacosamide (LCM) is related to slow inactivation of sodium channels. It is not known at this stage whether its efficacy is mostly associated with antiepileptic drugs (AED) with a particular mechanism of action. We try to determine if LCM is more effective when associated with AED blocking sodium channels or other AED. Methods: Descriptive, observational study. Inclusion criteria: patients older than 16 years, refractory focal epilepsy treated with LCM as add-on therapy, stable doses for at least three months and a reduction in seizure frequency of at least 75% We analyzed: demographic data, seizure type, epileptic syndrome, monthly frequency of seizures (two months before and during 3 months with stable doses), tolerance and mechanism of action of AED Results: We studied 16 patients (5M, 11W) with reduction of seizures greater than 75%: mean age 33 years, average time of evolution: 21 years, mean seizures: 27 per month, average duration of therapy: 23 weeks. Epileptic syndrome: MTLE 31%, 43% TLE, FLE 6.5%, OLE 6.5%, 6.25% In 62.5% of patients LCM was associated with a sodium channel blocker AED (CBZ 80%, LMT 20%); the remaining 37.5% of patients associated LEV. Conclusions: In our study, lacosamide appears to act more effectively associated with sodium channel blockers AED in refractory focal epilepsy