Adult lifespan analysis of gray and white matter in temporal lobe epilepsy
Abstract number :
2.458
Submission category :
5. Neuro Imaging / 5A. Structural Imaging
Year :
2022
Submission ID :
2233038
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:29 AM
Authors :
Luciana Ramalho Pimentel-Silva, BS, PhD – University of Alberta; Clarissa Lin Yasuda, MD, PhD – University of Campinas; Guilherme Coco Beltramini, BS, PhD – University of Campinas; Min Liu, PhD – University of Alberta; Brunno Machado de Campos, BS, PhD – University of Campinas; Ana Carolina Coan, MD, PhD – University of Campinas; Christian Beaulieu, BS, PhD – University of Alberta; Fernando Cendes, MD, PhD – University of Campinas; Donald gross, MD, FRCP(C) – University of Alberta
This is a Late-Breaking abstract.
Rationale: Healthy aging is associated with progressive cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline running in parallel would suggest an initial insult but does not support accelerated decline secondary to seizures. Whether TLE patients demonstrate similar trajectories of age-related gray (GM) and white matter (WM) changes as compared to healthy controls remains uncertain.
Methods: 3D T1-weighted images and diffusion tensor imaging (DTI) was acquired at a single site in 170 TLE patients (aged 23-74 years) with MRI signs of unilateral hippocampal sclerosis (77 right) and 111 healthy controls (aged 26-80 years). Global volumes (gray matter, white matter, total brain and cerebrospinal fluid and fractional anisotropy (FA) of 10 white matter tracts (three portions of corpus callosum, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, body of fornix, dorsal and parahippocampal-cingulum and corticospinal tract) were compared between groups as a function of age.
Results: We found a significant reduction of total GM and WM volumes, and (FA) of all 10 tracts in TLE versus controls. For TLE patients, regression lines for GM and WM volumes and FA run in parallel to those from controls across the adult lifespan, although at lower FA for TLE, for all tracts except the parahippocampal-cingulum and corticospinal tract.
Conclusions: These results imply a developmental hindrance occurring earlier in life rather than accelerated atrophy/degeneration of brain structures in patients with TLE.
Funding: Canadian Institute of Health Research, CEPID BRAINN - FAPESP grant 2013/07559-3, Brazilian National Council for Scientific and Technological Development (CNPq), Canada Research Chairs
Neuro Imaging