AED WITHDRAWAL DURING VIDEO-EEG MONITORING IN CANDIDATES FOR EPILEPSY SURGERY
Abstract number :
1.407
Submission category :
Year :
2003
Submission ID :
3822
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Addison R. Bolanos, Daniel Narino, Felipe Quiroga, Margarita Benito, Edwin Ruiz, James J. Riviello, Sandra L. Helmers Neuroscience, Hospital Central de la Policia-HOCEN, Bogota, Colombia; Neurology, Children[apos]s Hospital, Boston, MA; Neurology, Emory U
There is a great deal information regarding to seizure semiology in patients candidate for epilepsy surgey. However, there is little information regarding to protocol for antiepileptic (AED) withdrawal before admision and during Video EEG monitoring. The aim of this study is to analize seizure ocurrence antiepileptic drug (AED) (abrupt) withdrawal during Video EEG monitoring in patients candidate for epilepsy surgery in order to establish the safety of a withdrawal protocol.
Patients candidate for epilepsy surgery phase I or II admitted in the Video EEG monitoring unit between 2001-2002 were included in the protocol study. AED[apos]s were withdrawn quickly in all the patients before the admission. 39 patients with frontal and temporal lobe epilepsy were included.
Video EEG monitoring lasted 3.5 days. During admission patients had significantly more complex seizures and secondarily generalized seizures. The average of seizures was 5.4 per patient. There was a direct relationship between AED withdrawn and seizure recurrence.
The group with temporal lobe seizures was mor prone to have early seizure manifestations and Electroencefalographic discahrges in comparison with the frontal group.
There was no status epilepticus. We observed the presence of Pseudoseizures or NES (Non epileptic seizures ) in both groups.
Withdrawal of AED[apos]s increase early seizure frecuency and severity in those patients candidate for epilepsy surgery during and before Video EEG monitoring decreasing the number of days in LTM (Long Term Monitoring) and reducing epilepsy surgery expenses.
However, further and well controled studies are necesary in order to define a safe protocol