An epilepsy network derived from human brain lesions and deep brain stimulation
Abstract number :
2.411
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2021
Submission ID :
1886499
Source :
www.aesnet.org
Presentation date :
12/5/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:56 AM
Authors :
Frederic Schaper, MD - Brigham and Women's Hospital, Harvard Medical School; Janne Nordberg, MD - Turku University; Alexander Cohen, MD PhD - Boston Children's Hospital; Joey Hsu, BSc - Beth Israel Deaconness Medical Center; Christopher Lin, BSc - Brigham and Women's Hospital; Michael Ferguson, PhD - Brigham and Women's Hospital; Shan Siddiqi, MD - Brigham and Women's Hospital; Louis Soussand, MSc - Boston Children's Hospital; Anderson Winkler, MD PhD - NIH; Marta Simo, MD PhD - L’Hospitalet del Llobregat; Jordi Bruna, MD PhD - L’Hospitalet del Llobregat; Sylvain Rheims, MD PhD - University of Lyon; Marc Guenot, MD PhD - University of Lyon; Marco Bucci, MD PhD - Turku University; Lauri Nummenmaa, MD PhD - Turku University; Albert Colon, MD PhD - Kempenhaeghe Epilepsy Center; Linda Ackermans, MD PhD - Maastricht University; Ellen Bubrick, MD - Brigham and Women's Hospital; Jurriaan Peters, MD PhD - Boston Children's Hospital; Ona Wu, PhD - Mass General Hospital; Natalia Rost, MD - Mass General Hospital; Jordan Grafman, MD PhD - Northwestern University; Rob Rouhl, MD PhD - Maastricht University; Yasin Temel, MD PhD - Maastricht University; Hal Blumenfeld, MD PhD - Yale University; Juho Joutsa, MD PhD - Turku University; Michael Fox, MD PhD - Brigham and Women's Hospital
Rationale: Focal epilepsy is increasingly conceptualized as a brain network disease, but the location of this network remains unknown. Lesion locations associated with epilepsy may help identify an epilepsy network and lead to new treatment targets.
Methods: We studied 701 stroke patients and analyzed the lesion locations associated with epilepsy (n = 76) or control (n = 625). Lesion locations were mapped to a common brain atlas and the brain network functionally connected to each lesion location was computed using human connectome data (n = 1000). Functional connections associated with stroke-related epilepsy were identified. Generalizability to epilepsy associated with other lesion types (n = 452) was assessed using a leave-one-lesion-type-out cross-validation. Finally, therapeutic relevance of these connections was assessed using outcome data from patients who received thalamic deep brain stimulation for drug resistant epilepsy (n = 30).
Results: Lesion locations associated with stroke-related epilepsy map to a specific brain network defined by functional connectivity to nodes in the substantia nigra, globus pallidus, and cerebellum. Connectivity to this network was associated with the risk of epilepsy across different lesion types and with therapeutic response to thalamic deep brain stimulation.
Conclusions: Brain lesions associated with epilepsy map to a specific brain network with therapeutic potential for neuromodulation in epilepsy.
Funding: Please list any funding that was received in support of this abstract.: American Epilepsy Society Postdoctoral Fellowship.
Neuro Imaging