Application of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) to Children with Pharmacoresistant Epilepsy
Abstract number :
3.351
Submission category :
11. Behavior/Neuropsychology/Language / 11B. Pediatrics
Year :
2023
Submission ID :
1062
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Lisa Ferguson, MA – Cleveland Clinic
Ana Arenivas, PhD MPH – Cleveland Clinic; Kayela Arrotta, PhD – Cleveland Clinic; Dace Almane, MS – Department of Neurology – University of Wisconsin School of Medicine and Public Health; Jana Jones, PhD – Department of Neurology – University of Wisconsin School of Medicine and Public Health; Anny Reyes, PhD – University of California San Diego; Carrie McDonald, PhD – University of California San Diego; Bruce Hermann, PhD – University of Wisconsin School of Medicine and Public Health; Robyn Busch, PhD – Cleveland Clinic
Rationale: The International Classification of Cognitive Disorders in Epilepsy (IC-CoDE), a consensus based, empirically driven approach to cognitive diagnostics in epilepsy research, was recently developed to better understand cognitive phenotypes and their clinical correlates in adults with epilepsy. This taxonomy produces relatively stable cognitive phenotypes in adults with TLE across different centers and cultures/languages and has been applied to other focal epilepsies in adults. The utility of this taxometric approach in pediatric epilepsies has not been examined. The current study applied the IC-CoDE taxonomy to a cohort of children with epilepsy.
Methods: One hundred sixty children (mean age=13, 46% female) with pharmacoresistant focal epilepsy completed neuropsychological assessment as part of their pre-surgical investigations. Assessments included two measures in each of the following cognitive domains: attention/processing speed, language, executive function, visuospatial skills, and memory. A cognitive domain was considered impaired if the patient scored <
Behavior