Approximate Entropy Measured During Single Pulse Electrical Stimulation Is a Potential Biomarker for Seizure Onset Zone
Abstract number :
2.071
Submission category :
3. Neurophysiology / 3E. Brain Stimulation
Year :
2023
Submission ID :
883
Source :
www.aesnet.org
Presentation date :
12/3/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Cindy Mei, BS – Yale University
Kelly Pu, BS – Neurology – Yale School of Medicine; Karen Kirunda, BS – Yale University; Dennis Spencer, MD – Chair Emiritus, Neurosurgery, Yale School of Medicine; Hitten Zaveri, PhD – Neurology – Yale School of Medicine; Adithya Sivaraju, MD – Neurology – Yale School of Medicine
Rationale: Approximately one-third of patients with epilepsy are refractory to antiseizure medications. Intracranial EEG (ICEEG) recordings may be required for additional localizing information prior to resective surgery or neuromodulation, but visual analysis of ictal ICEEG onsets may not be enough for accurate localization. Single pulse electrical stimulation (SPES) and evoked responses may help identify epileptogenic cortex.1 With this study, we aim to explore broadband ICEEG features induced by SPES that may be unique to the epileptogenic cortex.
Methods: Ten patients who underwent ICEEG monitoring for seizure onset localization at Yale New Haven Hospital between November 2020 and December 2021 were included in this study.
Neurophysiology