ARE PLASMA LEVELS OF LACOSAMIDE OF ANY VALUE?
Abstract number :
3.263
Submission category :
7. Antiepileptic Drugs
Year :
2012
Submission ID :
16440
Source :
www.aesnet.org
Presentation date :
11/30/2012 12:00:00 AM
Published date :
Sep 6, 2012, 12:16 PM
Authors :
B. Pedersen, J. B. Rasmussen
Rationale: Lacosamide (LCM) is a novel antiepileptic drug approved for use as add-on therapy in partial epilepsy and works as a slow acting sodium channel blocker. Does plasma levels of LCM correlate to doses of LCM. Methods: To determinate LCM a high performance liquid chromatography (HPLC) rutine method with UV detection was used. Ninety-three measurements in 70 patients with patial epilepsy and on LCM were performed. Results: Despite the limited number of determinations the plasma-levels of LCM showed a clear correlation and a therapeutic level of LCM can be proposed to be 12-35 micromoles/ml with a 80 % cut off level Conclusions: The suggested therapeutic interval for LCM needs to be validated by measurements in more patients
Antiepileptic Drugs