Authors :
Presenting Author: Jack Vogel, BA – University of Wisconsin-Madison
Dace Almane, MS – University of Wisconsin-Madison
Jessica Kania, BS – University of Wisconsin-Madison
Jana Jones, PhD – University of Wisconsin–Madison
Bruce Hermann, PhD – University of Wisconsin-Madison
Rationale:
Previous applications of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) have involved adults and youth with focal (temporal and frontal lobe) pharmacoresistant epilepsies as well as youth with new/recent onset uncomplicated mixed focal and generalized epilepsies. Here, for the first time, we examine the distribution of IC-CoDE phenotypes in a cohort of participants with Juvenile Myoclonic Epilepsy (JME) compared to healthy controls.
Methods:
77 children and young adults with JME (M=20.2 yrs, 67.5% female) and 63 healthy controls (M=19.4yrs, 57.1% female) completed a comprehensive neuropsychological evaluation assessing language, visuoperceptual/spatial, memory, executive function, and processing speed with the cognitive data processed through IC-CoDE. The distribution of IC-CoDE phenotypes between JME and control groups was compared and, within the JME group, the associations of intact versus impaired (of any type combined) was examined in relation to history of academic problems (yes/no), number of discrete seizure types (absence, myoclonic, generalized tonic-clonic), area deprivation index (ADI), and antiseizure medication mono- versus polytherapy.
Results:
Using the < -1.0 z threshold for the operational definition of cognitive domain impairment, the JME and control groups exhibited significantly different distributions of cognitive phenotypes (