ASSOCIATION BETWEEN TEMPORAL LOBE EPILEPSY AND ELECTROENCEPHALOGRAPHIC PATTERN OF IDIOPATHIC GENERALIZED EPILEPSY
Abstract number :
2.390
Submission category :
Year :
2003
Submission ID :
469
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Maria-Paola Valenti, Serge Chassagnon, Alexis Arzimanoglou, Anne De Saint Martin, Edouard Hirsch Epilepsy Unit, Neurology, Strasbourg, Alsace, France
Idiopathic Generalized Epilepsy (IGE) represents a well known electroclinical entity occasionally inherited. Temporal Lobe Epilepsy (TLE) is a form of focal epilepsy, often drug-resistant associated with febrile seizures (FS) and hippocampal sclerosis (HS). We reported three patients presenting a TLE with or without HS associated with an electroencephalographic pattern of IGE.
We performed familial and personal history, video-EEG monitoring in awake and sleep, neuropsychological and neuroradiological investigations. In one case we performed a pre-surgical protocol.
We studied two male patients and one female (mean age 10 years). We found an history of complicated FS in two cases. Clinical, electrophysiological and neuropsychological data suggested an unilateral TLE. EEG monitoring shows in all cases a marked pattern of IGE, symptomatic in one case of eyelid myoclonia. We found an unilateral HS in two cases and an isolated abnormal signal of temporal pole in one case on magnetic resonance imaging. In this case we performed a temporal lobectomy. This patient was seizure free and histopathological findings show a neuronal migration disorder of temporal pole.
Association between electroencephalographic pattern of IGE and TLE is rarely reported. Is this association an unusual genetic imprinting (IGE, FS and TLE) or a fortuitous coexistence of both entities?