Atypical Emotional Conflict Responses in Adolescents with Epilepsy Using Magnetoencephalography
Abstract number :
2.204
Submission category :
6. Cormorbidity (Somatic and Psychiatric)
Year :
2022
Submission ID :
2204013
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:23 AM
Authors :
F. Kathryn King, MS – University of Texas at Arlington; M. Scott Perry, MD – Medical Director, Neurology, Jane and John Justin Neurosciences Center; Christos Papadelis, PhD – Director of Research, Bioengineering, Jane and John Justin Neurosciences Center; Crystal Cooper, PhD – Principal Investigator, Neuroscience, Jane and John Justin Neurosciences Center
This abstract has been invited to present during the Broadening Representation Inclusion and Diversity by Growing Equity (BRIDGE) poster session.
Rationale: Patients with epilepsy often suffer from comorbid depression. Emotion dysregulation is postulated to play a role in depression and could be a potential mechanism for it as an epilepsy comorbidity. While well investigated in psychiatric disorders using magnetic resonance imaging, emotional conflict processing has not been investigated in epilepsy, nor have methods to better elucidate it’s time-course been used. Here, we examine the spatiotemporal responses of emotional conflict processing in adolescents with epilepsy using magnetoencephalography (MEG). We hypothesize that adolescents with epilepsy, relative to typically developing (TD) controls, will exhibit deficits in emotional conflict processing in behavioral and brain responses, which will include the insula, cingulate, and posterior parietal cortices.
Methods: Twenty-eight adolescents, including eight with epilepsy and 20 TD controls (aged 10-19), underwent MEG recording during an emotional face-word Stroop task. Participants responded to facial expressions presented in images with overlaid emotional words that were either congruent or incongruent with the expression. Response times and accuracy were compared between conditions and groups. MEG data were pre-processed and divided into epochs lasting from -1000 to 1000 ms with respect to participant’s response. Conflict (incongruent – congruent) source activity maps were computed with dynamic statistical parametric mapping (dSPM) and compared between groups using independent samples t-tests.
Results: TDs exhibited typical responses to emotional conflict, characterized by slower and less accurate responses to emotional conflict (ps < .05; Figure 1). Conversely, those with epilepsy responded similarly across conditions (ps > .20). Relative to TDs, those with epilepsy had greater activity in a region encompassing the left insula, seen lasting from 38 ms before to 39 ms after participant response, with a reactivation of the superior portion of this region seen from 412-455 ms post-response (ps < .001; Figure 2A-B). Greater activity was later seen in the left cingulate gyrus, extending to the inferior parietal cortex, from 699-741 ms post-response (p < .001, Figure 2C).
Cormorbidity (Somatic and Psychiatric)