Brain Temperature and Choline Mapping in Temporal Lobe Epilepsy and Depression
Abstract number :
2.459
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2022
Submission ID :
2233009
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:29 AM
Authors :
Mina Oates, Undergraduate Student – Haverford College; Ayushe Sharma, PhD Candidate – Neurology – University of Alabama at Birmingham; Rodolphe Nenert, PhD – Neurology – University of Alabama at Birmingham; Christina Mueller, PhD – University of Alabama at Birmingham; Jerzy Szaflarski, MD, PhD – University of Alabama at Birmingham
This is a Late-Breaking abstract.
Rationale: The mechanism of the bidirectional relationship between epilepsy and depression is not well understood. In this prospective cross-sectional study, we used magnetic resonance spectroscopic imaging and thermometry (MRSI-t) to investigate the link between brain temperature, choline and other neurometabolite levels, and depression in patients with temporal lobe epilepsy (TLE)._x000D_
Methods: Twenty-six patients with TLE and 26 healthy controls (HCs) with or without depression completed questionnaires and underwent imaging at 3T. Volumetric whole-brain echo-planar MRSI data (voxel size 4.375x4.375x5.625 mm) were reconstructed and processed within the Metabolite Imaging and Data Analysis System (MIDAS). Choline (CHO) was quantified as the ratio over creatine (CRE; CHO/CRE) and brain temperature (TCRE) was calculated based on the H2O shifts relative to stable CRE location on the ppm spectrum. N-acetylasparate was quantified as the ratio over creatine (NAA/CRE). The Hospital Anxiety and Depression Scale (HADS) measured anxiety and depressive symptoms. The Chalfont Seizure Severity Scale (CSSS) measured seizure severity (TLE only). A series of two-way ANOVAS and voxelwise independent sample t-tests computed group differences. We used multivariate canonical correlation analysis (mCCA) to correlate group differences by brain region. _x000D_
Results: TLE participants showed significant CHO/CRE and TCRE elevations in the temporal lobe, ipsilateral to seizure onset (Figure 1). In TLE participants, higher CHO/CRE ratio was linked to elevated TCRE in the transverse, superior, and middle temporal and supramarginal gyri. Lower TCRE was significantly correlated with higher HADS-D scores in the supplementary motor area across both TLE and HCs. Additionally, CHO/CRE elevations were spatially linked with decreased TCRE in the anterior cingulate, frontal gyrus, paracentral lobule, and cingulate gyrus (Figure1, Table 1). Lower NAA/CRE levels were significantly associated with higher HADS-D scores in the frontal lobe and precuneus. TLE participants had higher depression scores than HCs (HADS-D, p=0.041) and seizure severity was positively correlated with HADS scores (both scales p=0.003). _x000D_
Conclusions: Our findings suggest that depressive symptoms may share similar neurobiological origins with neuroinflammatory processes that underlie TLE. This has important implications for treatment, as it suggests that targeting the mechanisms underlying epilepsy may be an effective way of mitigating depression and vice versa._x000D_
Funding: State of Alabama General Fund and the UAB Epilepsy Center supported this study. Ayushe Sharma was supported by an institutional training grant (T32-NS061788-13) from the National Institute of Neurological Disorders and Stroke (NINDS).
Neuro Imaging