Abstracts

Levetiracetam has been approved as adjunctive therapy in the treatment of partial onset seizures in adults. However, in clinical practice we have utilized levetiracetam as monotherapy across a spectrum of multiple seizure types in an adult population with epilepsy. This includes conversion to monotherapy from other anticonvulsants as well as initial drug therapy for newly diagnosed seizure disorder. We retrospectively reviewed records in 22 patients in which levetiracetam was used as monotherapy. Seizure types treated included: simple and complex partial seizures with or without secondarily generalization and primary generalized seizures, including myoclonic seizures. Our patients maintained good to excellent seizure control with levetiracetam monotherapy, allowing us to continue them on a single medication. This degree of seizure control spanned the spectrum of multiple seizure types. Levetiracetam proved effective as monotherapy in the treatment of various seizure types in an adult epilepsy population. (Supported by UCB Pharma, Inc.)