Co-Lateralization of Language and Memory: Is Knowing Language Dominance Enough in Presurgical Planning?
Abstract number :
1.348
Submission category :
11. Behavior/Neuropsychology/Language / 11A. Adult
Year :
2023
Submission ID :
264
Source :
www.aesnet.org
Presentation date :
12/2/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Alena Stasenko, PhD – UC San Diego
Erik Kaestner, PhD – UC San Diego; Jonathan Rodriguez, B.S – UC San Diego; Amanda Gooding, PhD – UC San Diego; Marc Norman, PhD – UC San Diego; Carrie McDonald, PhD – UC San Diego
Rationale: Evaluation of language and memory lateralization is important for predicting risk for post-surgical language and memory decline. For language lateralization, both the Wada procedure and fMRI are used given high reliability among them. Reports that fMRI language lateralization correlates with post-surgical verbal memory outcomes suggest that knowledge of language dominance may be enough to predict both language and memory outcomes. However, to our knowledge, no study has systematically compared co-lateralization of language and memory using a causal (i.e., de-activation) technique to support this possibility. We examined rates of co-lateralization of language and memory function assessed with the Wada, and variables that may predict discordance. We hypothesized that if language and memory re-organize in concert, then they should be highly co-lateralized, which would be consistent with previous fMRI studies.
Methods: Fifty-three individuals (n=41 with epilepsy; 22/17/2 with a left/right/bilateral seizure focus and n=12 with brain tumor) completed Wada language and memory testing. Language lateralization was classified as left/right/bilateral based on evidence of speech arrest/aphasia. Memory lateralization was determined based on left vs right memory recognition discriminability scores using a 10% cut-off (< 10%=bilateral).
Behavior