COMPARISON OF CLONIDINE TO SLEEP DEPRIVATION IN THEIR POTENTIAL ABILITY TO INDUCE SPIKE OR SHARP-WAVE ACTIVITY
Abstract number :
3.190
Submission category :
Year :
2002
Submission ID :
99
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Birgit Kettenmann, Michael Feichtinger, Christian Tilz, Martin Kaltenhäuser, Cornelia Hummel, Hermann Stefan. Neurology, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany
RATIONALE: The aim of the study was to investigate previously observed side effects, i.e. increased spike or sharp-wave activity in epileptic patients during clonidine medication. This study aims to reproduce this effect in a larger number of epileptic patients and to test safety and effectiveness of clonidine as spike inducing pre-medication compared to sleep deprivation.
METHODS: Recording was done using a magnetoencephalographic (MEG)-system. 22 patients took part in 3 sessions. Sessions were either performed after sleep deprivation or after medication with clonidine. For baseline one session was recorded without any of the two activating measures. Target parameter was the number of spikes or sharp-waves during a 30 minutes data acquisition period.
RESULTS: 67% of the patients showed an increase in spike activity after clonidine medication. After sleep deprivation the number of spikes increased in 33% of the patients. 29% didn[scquote]t show any activation at all. Clonidine was more effective in patients with an epileptic focus in the right hemisphere compared to patients with a focus in the left hemisphere. Serum concentrations ranging between 0.6 and 1.0 ng / ml were most effective.
CONCLUSIONS: Clonidine can be considered as a safe and effective spike or sharp-wave inducing drug that is superior to the spike inducing potency of sleep deprivation.
[Supported by: This research was supported by the ELAN grant from the University of Erlangen-Nuremberg.]