Comparison of Seizure Onset Patterns With Stereotactic EEG (sEEG) and Chronic Electroencephalography (Ecog)
Abstract number :
3.135
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2018
Submission ID :
502740
Source :
www.aesnet.org
Presentation date :
12/3/2018 1:55:12 PM
Published date :
Nov 5, 2018, 18:00 PM
Authors :
Erik Valenti, University of California - Irvine; Michael Young, University of California - Irvine; Sumeet Vadera, University of California - Irvine; Jack J. Lin, University of California - Irvine; and Lilit Mnatsakanyan, University of California - Irvine
Rationale: The aim of this study is to compare the seizure onset patterns between sEEG and chronic Ecog to determine whether the precise placement of responsive neurostimulation (RNS) electrodes to capture the seizure onset determined by sEEG would predict more accurate detections of seizure onset, and ultimately more effective therapy. Methods: A retrospective chart review identified twenty patients who underwent RNS implantation from 2015 to 2017 at our institution after intracranial monitoring detected > 1 seizure onset foci (SOZ) or seizures localized in the eloquent cortex. The neurostimulator was programmed to detect ictal onset and deliver the therapy to abort the seizures. Samples of Ecog were analyzed and compared to intracranial sEEG. Patient self-reported seizure control was then assessed at the last follow up. Two patients were excluded from the data analysis as they were skip candidates. One patient was excluded due to lack of detected Ecog seizures. Three patients had subdural strips implanted. Results: Fourteen patients met the inclusion criteria. Ten (71.4%) showed concordance between seizure onset pattern between SEEG and chronic Ecog. Four (28.6%) patients did not show definite correlate. Of the patients with concordant data, 90% reported seizure reduction and 50% of the non correlating showed seizure reduction. Conclusions: This preliminary data suggests that precise implantation of the RNS electrodes aiming to target the seizure onset zone determined by intracranial EEG may help to improve the therapy outcomes. Our study was limited by small sample size. The differences between groups may not be statistically significant. Funding: No funding was received in support of this abstract.