Abstracts

Rationale: Introduction: Epilepsy is a chronic neurological disorder characterizes with paroxysmal neuronal discharges .Antiepileptic drugs could affect quality of life on this patient, so we investigated cognitive dysfunction specially memory function fallowing antiepileptic drugs consumption. Methods: Methods: In this study, the ways for the treatment of the patients included: 1) Polytherapy treatment for more than one year (old and new generations of antiepileptic drugs); 2) Monotherapy treatment for more than one year (old or new generations of antiepileptic drugs) 3) Antiepileptic drugs for less than one year. The patients were those admitted to the neurological clinics from April 2015 to September 2015.The sample size in the study was consistent with the study population, and included the patients who had the inclusion criteria of the study. According to the previous studies, the prevalence of cognitive complications in epileptic patients was 25%. Therefore, the sample size was calculated using the following formula: N={ZI(1/2)^2*P(1-P)}/d^2=3.84*0.25(1-0)/(0.08)^2=112.5 Results: Methods: In this study, the ways for the treatment of the patients included: 1) Polytherapy treatment for more than one year (old and new generations of antiepileptic drugs); 2) Monotherapy treatment for more than one year (old or new generations of antiepileptic drugs) 3) Antiepileptic drugs for less than one year. The patients were those admitted to the neurological clinics from April 2015 to September 2015.The sample size in the study was consistent with the study population, and included the patients who had the inclusion criteria of the study. According to the previous studies, the prevalence of cognitive complications in epileptic patients was 25%. Therefore, the sample size was calculated using the following formula: N={ZI(1/2)^2*P(1-P)}/d^2=3.84*0.25(1-0)/(0.08)^2=112.5 Conclusions: Results: There were not any statistical differences between the groups in terms of the rates of attention, memory, lingual ability, speech flow, and visual-spatial ability (p>0.05).However, the ANOVA test showed that the mean of memory (recalling) in the monotherapy group was higher than the means in the monotherapy and the control groups(60vs 10), showing a statistically significant difference (p < 0.05). Funding: 200 US $