Abstracts

This is a Late Breaking abstract

Rationale: For thousands of years, Cannabis sativa has been utilized for spiritual, recreational and medicine purpose. Cannabidiol (CBD) and trans-∆-9-tetrahydrocannabinol are the phytocannabinoids known with physiological and psychotogenic effects. CBD the non-toxic compound has being proved of its antiseizures effects mainly by binding to endogenous cannabinoid receptors, CB1 and CB2. THC because its highly lipophilic qualities rapidly distributes to the brain being responsible of the neurotoxic effects. So, according to EU law, CBD products must not contain more than 0.2% THC. Class I evidence based on placebo-controlled RCTs that pure form of CBD is therapeutic option for certain types of epilepsy syndromes was stablished  in 2018. Its main uses are in Dravet syndrome, Lennox Gastaut syndrome and recently tuberous Sclerosis complex epilepsy. Unfortunately the wrong conception that CBD products are “natural and non-harmful" has  promote that non well informed  physicians prescribe and  stimulate  parents with refractory and non refractory epileptic children to manufacture their own CBD or buy non-certified products sold has “pure CBD” as an antiseizure medication without knowing  real compounds  and concentration of CBD and THC with the risk of  being exposed to well-known short and long adverse effects. The aim of this study was analyzed the composition of CBD Artisanal products , voluntary given by parent for its analysis. Its origin was from homemade CBD oil or commercial product sold as pure CBD  legally and no legally recognized by Chilean public health institute (ISP) as antiseizure drug

Methods: A total of 35 samples were collected, 2 LCS, 6 NLCS and 27  HMS between March 2020 and September 2021. None of the samples had the concentration declared of CBD (100mg /ml). LCS were pure with high concentration of CBD and acceptable concentration of  THC(average: CBD 89,15mg /ml /THC 0,015). NLS had low levels of CBD with unacceptable levels of THC but much lower in comparison with HMS._x000D_ HMS showed much higher and highly variable concentrations of THC with an average and rage of  CBD 1,83 ( 0 – 6,6)/  16,03 (0- 388mg/ml).

Results: A total of 3535 samples were collected, 2 LCS, 6 NLCS and 27  HMS between March 2020 and September 2021. None of the samples had the concentration declared of CBD (100mg /ml). LCS were pure with high concentration of CBD and acceptable concentration of  THC (average: CBD 89,15mg /ml /THC 0,015). NLS had low levels of CBD with unacceptable levels of THC but much lower in comparison with HMS. HMS showed much higher and highly variable concentrations of THC with an average and rage of  CBD 1,83 ( 0 – 6,6)/  16,03 (0- 388mg/ml)._x000D_ _x000D_ Conclusions: Medical community must be well informed  and make the population aware that Hemp products are not innocuous. HMS are highly prompted to have high levels of  THC and very low in CBD, with neurotoxic levels of THC, far away  from therapeutic doses of CBD. CBD use in epilepsy should be restricted to licensed products especially in children where THC toxicity is greater._x000D_
Funding: None