Defining Surgical Outcome Using Phase-Amplitude Coupling in Electrocorticogram for Human Temporal Lobe Epilepsy
Abstract number :
2.015
Submission category :
3. Neurophysiology / 3A. Video EEG Epilepsy-Monitoring
Year :
2018
Submission ID :
501816
Source :
www.aesnet.org
Presentation date :
12/2/2018 4:04:48 PM
Published date :
Nov 5, 2018, 18:00 PM
Authors :
Guoping Ren, Beijing Tiantan Hospital, Capital Medical University; Jiaqing Yan, North China University of Technology; Dan Wang, Xingtai People’s Hospital of Hebei Province; Jindong Dai, Beijing Haidian Hospital; Yunlin Li, Children's Hospital Affili
Rationale: Some researches have observed that the phase of low frequency activities (delta, theta, alpha, beta) can modulate high frequency activities (beta, ripples, fast ripples) in epileptogenic zone. This research compared the phase-amplitude coupling (PAC) of different frequencies in the removed and unremoved channels in temporal refractory epileptic patients who had good surgical outcome with those who had bad outcome, aiming at exploring the correlation between PAC in electrocorticogram with surgical outcome. Methods: Six patients with intractable temporal epilepsy, who underwent intracranial electroencephalography (iEEG) motoring and subsequent epileptogenic zone resection at Epilepsy Center of Beijing Haidian Hospital from January 2013 and December 2014, were enrolled in this study, and their clinical data were retrospectively studied. The patients were classified as good (Engel ?) and bad outcome groups (Engel ?-?) according to their seizure condition. We randomly selected 1-min iEEG data from interictal period in slow wave sleep, and then computed PAC index between different low and high frequency activities in each channel. The differences of average PAC index in removed and unremoved channels between good and bad outcomes was compared. Results: Both good and bad outcome groups have three patients. In removed channels, the average PAC index of good outcome group (n=64) between alpha and fast ripples(p=0.009), beta and ripples(p=0.004), beta and fast ripples(<0.001) are significantly higher than those in bad outcome group (n=49);In unremoved channels, the average PAC index of good outcome group (n=29) between theta and gamma band (p=0.02) is significantly less than that of bad outcome group (n=44). Conclusions: Good surgical outcome is correlated with resection of channels with increased PAC index between theta, alpha, beta and all high frequency activities. The EEG PAC analysis maybe an effective method to assist location of epileptogenic zone. Funding: Epilepsy research fund of China Association Against Epilepsy-UCB fund (2018013)Youth research fund of Beijing Tiantan Hospital affiliated to Capital Medical University (2017-YQN-01)The capital health research and development of special(2016-1-2011)