Abstracts

Rationale: To verify the association of dysfunctional beliefs of personality disorders with the executive performance in people with juvenile myoclonic epilepsy (JME). Methods: Patients with JME were submitted to the Personality Disorders Beliefs Questionnaire (PBQ) (Beck & Beck, 1991), Revised Personality Inventory (NEO PI-R) (Costa & McCrae, 1990), Disexecutive Questionnaire (Wilson et al.,1996), estimated Intelligence Quotient (IQ) using Vocabulary and Block Design Tasks (Spreen & Strauss, 2006), Atention and Executive Functions evaluation (Controlled Oral Word Association (COWA), Digit Span, Trail Making Tests (TMT) A and B, Stroop, Rey Complex Figure test (RCF) II and Wisconsin Card Sorting Test (WCST)). Inclusion criteria were: diagnosis of JME (ILAE, 1989); age >=18yrs., schooling >=11yrs. and estimated IQ >=70. Inclusion criteria for the control group were: age >=18yrs., schooling >=11yrs, no neurological or psychiatry history. Results: Fifty-two patients (35 women, 67.3%) aged 18-50yrs. (32.3+9.7) were evaluated between May 2017 and April 2019 and compared to 197 controls. Patients presented higher scores in PBQ for personality traits: Narcissistic (z=-0.79; p<0.001), Borderline (z=-0.58; p=0.002), Paranoid (z=-0.43; p=0.017) and Histrionic (z=-0.39; p=0.041); as well as in NEO PI-R for Neuroticism (z=-0.44; p=0.011), Openness (z=-0.47; p=0.016), and Conscientiousness (z=-0.42; p=0.019). PBQ traits showed correlation with NEO PI-R results: negative for Borderline with Openness (r=-0.317; p=0.034) and positive for Narcissistic with Extroversion (r=0.303; p=0.043) and Histrionic with Extroversion (r=0.318; p=0.033). Executive functions were impaired compared to controls in the tests: TMT A (z=-0.97; p=0.038), TMT B (z=-0.65; p=0.023) and COWA (z=-0.51; p=0.001). Patients showed higher WCST scores for Errors (z=-1.62; p=0.001), Perseverative Errors (z=-0.77; p=0.001), Non-Perseverative Errors (z=-1.01; p=0.002), Conceptual Level Response (z=-1.56; p=0.001) and Completed Categories (z=-2.12; p=0.002). PBQ traits showed correlation with lower values in TMT A: Antisocial (r=0.298; p=0.032), Narcissistic (r=-0.303; p=0.029), Schizoid (r=-0.410; p=0.003), Histrionic (r=-0,341; p=0,013) and Obsessive-Compulsive (r=-0,359; p=0,009); TMT B results showed a trend for Obsessive-Compulsive trait (r=-0.271; p=0.052); COWA was correlated to Dependent (r=+0.319; p=0.021); TMT A (r=-0.334; p=0.0015) and Digits Span (r=+0.287; p=0.039) to Passive Aggressive. On WCST, Failure to Maintain the Context was correlated to Schizoid (r=0.335; p=0.017). Disexecutive questionnaire was not correlated with none of the PBQ and NEO-PIR results and it was only correlated to RCF II (r=-0.275; p=0.048). Conclusions: People with JME presented dysfunctional beliefs and traits for personality disorder which were correlated with executive dysfunction. These findings reinforce the need of psychological rehabilitation in these patients. Funding: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) -Finance Code 001.