Does glucose influence multidien cycles of interictal and/or ictal activities?
Abstract number :
270
Submission category :
3. Neurophysiology / 3E. Brain Stimulation
Year :
2020
Submission ID :
2422616
Source :
www.aesnet.org
Presentation date :
12/6/2020 12:00:00 PM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
Sanjay Kubsad, University of Washington School of Medicine; Alexa Pappas - University of Southern California; Maxime Baud - Sleep-Wake-Epilepsy-Center, Department of Neurology, Inselspital, University Hospital; Kyla Wright - New York University School of
Rationale:
There are multidien patterns of seizure occurrence. Predicting seizure risk may be easier with biomarker correlates to multidien patterns. In a type I diabetic with focal onset epilepsy patient with continuous glucose monitoring (CGM) and responsive neurostimulation (RNS) devices, we studied multiday interictal activities (IEA), seizures, and glucose patterns. We hypothesized multiday hyper or hypoglycemia would contribute to seizure risk.
Method:
Hourly CGM data was matched to hourly RNS captures of interictal and ictal activities over 33 months. RNS detection settings were unchanged. Multidien cycles were analyzed, active blocks of IEA and ictal episodes defined, and tissue glucose averages studied.
Results:
Average glucose was 161 mg/dl. A 40-day cycle of interictal and ictal activities occurred, though no similar glucose cycle was evident. Glucose elevations relative to patient average were associated with increases in IEA but not seizure. Frequent seizures were not associated with obvious elevations or decreases of glucose from our patient’s baseline, most seizures occurred at +/- 10 mg/dl of average daily glucose (i.e. 150- 170 mg/dl).
Conclusion:
Tissue glucose may influence IEA but may not influence multiday seizure activity or very frequent seizures. In an ambulatory T1D patient multiday hypo or hyperglycemic extremes do not appear to provoke seizure activities.
Funding:
:None
Neurophysiology