Dual Neuromodulation Effect on Seizure Frequency a Case Report
Abstract number :
3.419
Submission category :
18. Case Studies
Year :
2023
Submission ID :
1185
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Philip McCarthy, DO – Corewell Health
David Burdette, MD – Corewell Health
Rationale: The aim of this study is to illuminate the interaction of dual neuromodulation devices on epilepsy networks utilizing a two patient case series.
Methods: Two patients were selected from the authors' institution who have both a deep brain stimulator (DBS) and responsive neurostimulator (RNS) devices implanted for medically refractory epilepsy. The cases were chart reviewed, device settings were reviewed, as well as medication adjustments over the course of their implants. The Neuropace Patient Data Management System (PDMS) was reviewed for captured data sets and analyzed for seizure patterns as well as aliased DBS frequencies. This information was analyzed to see if there was a correlation between DBS and RNS activity. If the DBS was firing before, during, or after RNS capture and therapies were being delivered.
Results: Results are as follows:
Case 1: Seizure freedom with low frequency stimulation on DBS.
Case 2: Seizures continue though without a relation to DBS firing.
Conclusions: Based on the results of the two case studies, this would suggest there is a modulating network connection from the centromedian nucleus of the thalamus through stimulation at lower frequencies, 5 Hz, that provides a benefit to seizure modulation that is not represented at higher frequency stimulation, 145 Hz.
Funding: None.
Case Studies