Authors :
Presenting Author: Jeff Gaither, PhD – Nationwide Children's Hospital
Ammar Shaikhouni, M.D./Ph.D. – Pediatric Neurosurgeon, Nationwide Children's Hospital; Adam Osftendorf, M.D. – Pediatric Neurologist, Nationwide Children's Hospital; Jonathan Pindrik, M.D. – Pediatric Neurosurgeon, Nationwide Children's Hospital; Stephanie Ahrens, DO – Pediatric Neurologist, Nationwide Children's Hospital; Christopher Beatty, M.D. – Pediatric Neurologist, Nationwide Children's Hospital
Rationale:
Corpus callosotomy (CC) is a palliative surgical procedure that is effective at decreasing seizure frequency or severity in patients with intractable epilepsy. However, not all patients benefit from the procedure. Here we examine the EEG of patients before and after complete corpus callosotomy to look for EEG patterns which correlate with successful post-op patient reported outcomes.
Methods:
We obtained pre and post operative 10-20 clinical EEG data from 14 CC patients with three having outcome of Engel IIB or better and remainder with Engle class lower than IIB. We calculated pre and post EEG interhemispheric coherence in the 4-30Hz band across pairs of electrodes in 30s intervals repeated every 15 minutes across the first four hour of both EEG studies. We compared the average coherence values across electrode pairs for the patient with Engel class IIB outcome or better to those with worse outcomes. Analysis was performed in Python using the MNE toolbox.
Results:
We found a significantly higher coherence in the 4-30Hz band in post-CC EEG in the patient with Engle Class IIB or better outcomes compared to those with worse outcomes (see figure). This difference was not apparent in the preop EEG.
Conclusions:
Higher 4-30Hz band coherence in post EEG may serve as a marker for improved outcome after CC surgery that may supplement patient reported surgery frequency and severity data. Whether this measure can be used to predict outcomes based on preop EEG requires further study.
Funding: None