Abstracts

Rationale: Have been described different ictal and interictal electroencephalographic patterns in children with the Lennox-Gastaut syndrome (LGS) with little data in adults, the objective is to describe this patterns in a patient with this pathology. Methods: Case report Results: A 47-year- old male had a history of perinatal hypoxia and a diagnosis of LGS. He had atypical absences, tonic and tonic-clonic seizures. Treatment: LTG, VPA, CLB. Interictal video-EEG showed slowing of the background activity (range 5-7 Hz), frequent burst of non-rhythmic polymorphic slow waves in the delta-theta range, polyspikes, slow spike and wave (SW) discharges of 1.5-2.5 Hz, this discharges were generalized and multifocal. In addition, EEG showed bursts generalized of fast activity of 14-16 Hz and absence of normal sleep hallmarks. Ictal video-EEG: the most tonic seizures related to busts of fast activity of 14-16 Hz, in another events generalized voltage attenuation with 2 seconds of duration were observed. The postictal showed suppression of electrical activity followed by generalized slow waves with a maximum duration of 10 seconds. Conclusions: There are few studies focused on the description of electroencephalographic patterns 1,2,3 in adult patients with LGS, the findings include: slowing of the background activity, SW discharges of 1.5 to 2.5 Hz, generalized voltage attenuation and bursts of fast activity of 10 at 25 Hz. These patterns are similar to those we found in our patient, although the absence of normal sleep hallmarks and the ictal pattern conformed by bursts of fast activity were the most frequent findings.REFERENCES1.            Hrachovy RA, Frost JD Jr. J Clin Neurophysiol. 2006 Aug;23(4):312-32.2.            Asadi-Pooya AA, Sharifzade M. Seizure. 2012 Dec;21(10):760-3.3.            Sforza E, Mahdi R, Roche F, Maeder M, Foletti G. Epileptic Disord. 2016 Mar;18(1):44-50. Funding: I did not receive any funding.