EFFECT OF KETOGENIC DIET ON THE CONTINUING SEIZURES OF PTZ-INDUCED SEIZURE MODELS IN RATS
Abstract number :
1.053
Submission category :
Year :
2002
Submission ID :
1606
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Jae-Moon Kim, Ki-Young Jung, Dong-Wook Kim. Neurology, Chungnam National University Hospital, Daejeon, Korea; Neurology, Chungnam National University Hospital, Daejeon, Korea; Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea
RATIONALE: Ketogenic diet (KD) significantly attenuates refractory epilepsy in certain patients. Also, evidence of therapeutic efficacy of KD was proved in variety of animal models. To evaluate the effect of KD on the status epilepticus, continuing seizure in PTZ-induced seizure models were analyzed.
METHODS: Postnatal 3, 6, 9, and 12 weeks rats were divided into ketogenic diet (KD-3,6,9,12 group) and regular diet group (RD-3,6,9,12 group). Each group has more than 18 rats and total number of rats were 169. After a day of fasting KD was maintained for 3 weeks in KD group. Seizure was induced three weeks of diet and seizure severity and duration of continuing seizure was evaluated.
RESULTS: Ongoing seizure was induced in 17 rats in KD group and 19 in RD group. Three rats were died of SE in KD group and 6 in RD group. Duration of SE was 6.07 (KD) vs. 9.89 minutes (RD). These differences were most prominent in postnatal 6 weeks and 9 weeks group.
CONCLUSIONS: KD significantly reduces ongoing seizure in PTZ-induced seizure in rats.
[Supported by: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea. (HMP-99-N-02-0003)]