EFFECT OF TOPIRAMATE ON THE CHANGES OF IL-1[beta],TNF[alpha] AND NO IN SERUM AND CSF IN EPILEPSY PATIENTS
Abstract number :
2.243
Submission category :
Year :
2002
Submission ID :
90
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Hong Zhang, Yuanyuan Hu, Etang Tong. Psychology Department, University of Michigan, Ann Arbor, MI; Radiation Oncology, University of Michigan, Ann Arbor, MI; Department of Neurology, Union Hospital,Tongji Medical College of HUST, Wuhan, Hubei, China
RATIONALE: To study the probable mechanism of topiramate(TMP) in the pathogenesis of epilepsy.
METHODS: The levels of interleukin-1beta (IL-1[beta]), tumor necrosis factor alpha (TNF[alpha]) and nitric oxide (NO) production-nitrite (NO2) in serum and cerebrospinal fluid of 48 epilepsy patients and 27 normal subjects were measured with radioimmunoassay and fluorometric method.
RESULTS: The levels of IL-1[beta], TNF[alpha] and NO2 in serum and CSF were significant higher than those in normal subjects (p[lt]0.01).Treatment with topiramate (TMP) decreased the levels of IL-1[beta], TNF[alpha] and NO2 in serum and CSF of epilepsy (p[lt]0.05 or p[lt]0.01), but still higher than normal subjects (p[lt]0.01). Combined treatment with topiramate(TMP) and flunarizine(FNR), serum IL-1[beta], TNF[alpha] and NO2 in epilepsy were not significantly difference from the normal subjects (p[gt]0.05),but the levels of TNF[alpha] and NO2 in CSF were still higher than those in normal subjects (p[lt]0.05 or p[lt]0.01).
CONCLUSIONS: The pharmacological effect of topiramate is associated with the pathogenesis of epilepsy and this effect will enforce as combines with the flunarizine.[table1][table2]
[Supported by: Partly supported by China Janssen Pharmaceutica]