Abstracts

This study was performed to investigate the effects of antiepileptic drugs according to the patterns of characteristic EEG progression in the lithium-pilocarpine induced status epilepsticus (SE). Male Sprague-Dawley rats weighing 200-300grams were used as subjects. SE was induced 7 days after placement of epidural electrodes, by lithium pretreatment followed by low dose of pilocarpine i.p.(30mg/kg). The intracranial EEG was continuously recorded from pilocarpine injection until the end of SE. The pattern of EEG were divided into 5 stages; discrete ictal discharge (d), merging stage, continuous ictal discharge stage (c), continuous ictal discharge with flat period (f), periodic epileptiform discharge stage. Phenytoin (30mg/Kg, PHT), valproate (100mg/Kg, VPA) and phenytoin with valproate (PNT+VPA) were injected during discrete (d), continuous ictal discharge (c), continuous ictal discharge with flat period stages (f), respectively. SE was induced in 78/96 (81.3%). The mortality was 20%(2/10) in control group, 14.3% (3/21) in PHT treated group, 18.2% (4/22) in VPA group and 8% (2/25) in PHT+VPA group. In control group, duration of total EEG seizure was 1008.0[plusmn]89.47 minutes. Continuous stage significantly was shortened in VPA-d group and PHT+VPA-d group compared to control group (p[lt]0.05). Also, the durations of the periodic epileptiform discharge stage and total seizure were reduced in VPA-d, PHT+VPA-d and PNT+VPA-c groups (p[lt]0.05). This results suggest that analysis of progressive EEG pattern in SE may predict the prognosis of SE and response to treatment. And early treatment according to EEG monitoring and polytherapy are effective treatment in SE.