Effects of Long-Term Video-EEG Monitoring on Mood in Epilepsy Patients.
Abstract number :
3.101
Submission category :
Year :
2001
Submission ID :
957
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
B.A. Malow, M.D., M.S., Neurology, University of Michigan, Ann Arbor, MI; K. Bristol, Neurology, University of Michigan, Ann Arbor, MI; A. Natarajan, M.S., Biostatistics, University of Michigan, Ann Arbor, MI; X. Lin, Ph.D., Biostatistics, University of M
RATIONALE: To examine changes in mood of epilepsy patients during long-term video-EEG monitoring (LTM). While the effects of antiepileptic drug (AED) taper on mood have been studied previously, the effects of sleep deprivation on mood during LTM have received little attention. Our hypothesis is that sleep deprivation and AED taper adversely alter mood.
METHODS: Seventy-nine epilepsy surgery candidates (40 men, 39 women, ages 18-59 years) completed the Profile of Mood States (POMS) during phase I monitoring. The six mood dimensions were examined at baseline, for changes in mood between baseline and day 3, and between baseline and day 8 or the final day of the protocol. Subjects were consecutively assigned in groups of five to sleep deprivation every other night or to normal sleep. All subjects were tapered off AEDs during monitoring using standard guidelines in our laboratory. Statistical linear models were applied to assess the effects of age, gender, seizures, sleep deprivation, and taper of AEDs on mood.
RESULTS: Sleep deprivation increased fatigue and decreased vigor from baseline to day 3 (p = 0.003), but not from baseline to day 8 or the final day of the protocol (p [gt] 0.1). Taper of AEDs did not adversely affect mood, with removal of phenytoin improving tension (p = 0.03), anger (p = 0.01), and depression (p = 0.003) from baseline to day 8 or the final day of the protocol. Subjects who had seizures during LTM also improved in depression (p = 0.04). Differences in medication taper rates for the sleep deprived and normal sleep groups were not statistically significant (p [gt] 0.1; two-tailed, two-sample t-test).
CONCLUSIONS: Overall, our data indicate that LTM does not adversely affect mood. Mood may actually improve in those tapered off phenytoin and in those who have seizures during LTM. However, in the first few days of LTM, sleep deprivation may produce fatigue and lack of vigor, and should be used only as needed to provoke seizures.
Support: NINDS K02 NS02099