Abstracts

Rationale:
To review the efficacy of clobazam in Dravet syndrome .
Method:
Retrospective cohort study review of patient with Dravet syndrome who were treated with Clobazam. The following information will be collected age, gender, weight, seizure type, frequency, pre and post, Clobazam dose, discontinuation, side effect, details of concomitant AED regimens. Results We have a total of 25 patients 5 of them are girls , and 120are boys . 19(76% ) of them showed improvement on clobazam in different semiology ,9 (591.6%) of patients with Myoclonic , 9(64.2% ) with tonic clonic and 3(75%) with absence .But 4(28.5%) patients of them with Tonic Clonic semiology showed no improvement .5 patients became seizure free in rang dose 0.4 mg/kg to 1.3 mg/kg . 2 out of 14(14.2%) with Tonic clonic became seizure free with clobazam at dose 1.3 mg/kg ,2 out of 12 (16.6%) with myoclonic became seizure free with 0.4 mg/kg to 0.9 mg/kg .1 out of 3 (33%) with tonic posture became free of seizure with clobazam at 0.9 mg/kg .2 patients with tonic clonic was on Levetiracetam and when we add clobazam they became seizure free . Two patient with myoclonic was on Levetiracetam  ,Topamax ,Valproic Acid they became seizure free One patient with tonic was on Levetiracetams and when we add clobazam he became seizure free .there is 3 (12% ) patients develop Side effect in form of sedition and one patient only his dose have been adjusted .There was no difference in patient age of starting clobazam or Sex .
Conclusion:
Clobazam showed significant improvement in 76% of the patient with dravet syndrome . And only 12 % showed side effect .Age and Sex did not affect the outcome of clobazam .
Funding:
:KFSHRC