Abstracts

Rationale: The incidence of convulsion after surgery for supratentorial intracranial disease as a non-traumatic lesion is reportedly 15 to 20%. In this study, we examined the effects of focal resection on refractory epilepsy following surgery for intracranial disease. Methods: The subjects were 7 patients who underwent surgery for intracranial disease before 2014, and in whom postoperative convulsive attacks could not be controlled with antiepileptic drugs. We retrospectively investigated their clinical courses. Results: Seven patients (3 males, 4 females) underwent craniotomy for intracranial disease. The mean age at the time of surgery was 38 years (range: 14 to 68 years). Intervals required for focal resection for refractory epilepsy after craniotomy ranged from 0 to 14 years, with a mean of 6 years. Intracranial diseases consisted of cerebral hemorrhage in 1 patient, subarachnoid hemorrhage in 2, glioblastoma in 1, oligodendroglioma in 2, and trigeminal neurinoma in 1. Concerning the type of epileptic seizures, complex partial seizures were noted in 4 patients, and partial seizures in 3. In these patients, surgery for epilepsy was performed. Surgical procedures consisted of focal resection in 3 patients, amygdalohippocampectomy in 1, vagal nerve stimulation (VNS) in 2, and the combination of VNS and amygdalohippocampectomy (due to unfavorable seizure control after VNS) in 1. The inhibitory effects on postoperative seizures were evaluated as Engel class 1a in 2 patients, 1b in 1, 1c in 1, 2a in 1, and 3a in 1. Epileptic seizure control reduced the patients’/their families’ mental stress. Conclusions: Surgery for refractory epilepsy after craniotomy inhibited seizures, reducing the patients’/their families’ mental stress. Funding: There was nobody for my support.