Abstracts

Electroencephalographic Changes Post Callosotomy and Clinical Relation with Seizure Control

Abstract number : 2.181
Submission category : 4. Clinical Epilepsy / 4D. Prognosis
Year : 2023
Submission ID : 881
Source : www.aesnet.org
Presentation date : 12/3/2023 12:00:00 AM
Published date :

Authors :
Presenting Author: Luisa Espaillat, MD – Clinica Corominas

Lisamelia Espaillat, MD – PUCMM; Miguel Venegas, MD – Neurosurgeon, Neurosurgery, Clinica Corominas; Smaylee Tavarez, MD – UTESA; Nadiwska Roa, MD – INTEC; Ana Peralta, MD – PUCMM

Rationale:

Refractory epilepsy accounts for about one-third of patients diagnosed with epilepsy. This has been shown to have an impact on psychomotor development, thus leading to greater regression and delay. The electroencephalogram (EEG) has been an important tool for the diagnosis and follow up of patients. Showing a diversity of patterns such as burst-suppression patterns, hypsarrhythmia and/or important focal activity. This article aims to describe the postoperative electroencephalographic changes of the patients who underwent callosotomy in a Center of the Dominican Republic.



Methods:

We retrospectively analyzed the medical records of four patients under fifteen years of age who attended the neurosurgery clinic of the Corominas Center in Santiago, Dominican Republic, for treatment-resistant epilepsy. All patients presented regression in motor development and speech at the time of consultation. MRI was performed, which showed no structural abnormalities in any of the patients. EEG did show generalized epileptiform activity with sharp waves, slow waves, and burst-suppression patterns in all patients.



Results:

All patients showed pre-surgical EEG spikes and sharp waves with a tendency to burst suppression. A month after the surgery, EEGs were performed on each patient. We observed that at least one patient persisted with a burst-suppression pattern and clinical seizures, one with focal activity and two without epileptic activity, all without clinical events. However, patients without epileptic activity, unlike the others, underwent a total callosotomy vs. partial.



Conclusions:

Surgical treatment with callosotomy is a useful tool in patients with refractory epilepsy. It has been demonstrated that with control of seizures, not only neurocognitive and social improvement is observed but also EEG changes, positively impacting the patient's and their caregiver's life.



Funding: No funding were received

Clinical Epilepsy