EpiBioS4Rx: Inflammatory Response to Brain Injury in a Lateral Fluid Percussion Injury Rat Model and Effect of Kineret
Abstract number :
3.112
Submission category :
2. Translational Research / 2C. Biomarkers
Year :
2021
Submission ID :
1826661
Source :
www.aesnet.org
Presentation date :
12/6/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:55 AM
Authors :
Lisa Coles, MS, PhD - University of Minnesota; Patricia Saletti - Albert Einstein College of Medicine, Bronx, New York; Christos Lisgaras - Albert Einstein College of Medicine, Bronx, New York; Qianyun Li - Albert Einstein College of Medicine, Bronx, New York; Wei liu - Albert Einstein College of Medicine, Bronx, New York; Pablo Casillas-espinosa - Monash University, Melbourne, Australia; Rhys Brady - Monash University, Melbourne, Australia; Idrish Ali - Monash University, Melbourne, Australia; Emma Braine - Monash University, Melbourne, Australia; Nigel Jones - Monash University, Melbourne, Australia; Sandy Shultz - Monash University, Melbourne, Australia; Juliana Silva - Monash University, Melbourne, Australia; Glenn Yamakawa - Monash University, Melbourne, Australia; Terence O’Brien - Monash University, Melbourne, Australia; Solomon Moshé - Albert Einstein College of Medicine, Bronx, New York; Aristea Galanopoulou - Albert Einstein College of Medicine, Bronx, New York
Rationale: Neuroinflammation is a known response to traumatic brain injury (TBI) and can result in acute and chronic secondary neurological damage, including post-traumatic epilepsy (PTE). Kineret, an interleukin 1 (IL-1) receptor antagonist, targets a prominent mediator of inflammation. While Kineret has been shown to be a potent anti-inflammatory agent, we have found the brain penetration in rats to be extremely low (brain-to-blood ratios of < 0.01). The objective of this work was to characterize the inflammatory response following lateral fluid percussion injury (LFPI) in rats, a TBI animal model that is well characterized to result in PTE in 30-50% of animals 6–12 months post-injury, and the effect of Kineret therapy.
Translational Research