Epidemiology of Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS): Retrospective Cohort Study
Abstract number :
2.394
Submission category :
16. Epidemiology
Year :
2023
Submission ID :
576
Source :
www.aesnet.org
Presentation date :
12/3/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Richard Chin, MRCPCH, PhD – The University of Edinburgh
Arron Lacey, PhD – Swansea University; Carys Jones, MChem – Swansea University; Jacqueline Stephen, PhD – The University of Edinburgh; Christopher Weir, PhD – The University of Edinburgh; William Pickrell, PhD, MRCP – Swansea University
Rationale:
Information on self-limited epilepsy with centrotemporal spikes (SeLECTS) epidemiology is limited. We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.
Methods:
We performed a retrospective cohort study (2004 through 2017) using anonymized, routinely collected, primary care and demographic data for children in Wales. We used primary care diagnosis codes to identify children (aged 0–16 years) with SeLECTS and other epilepsies and to record antiseizure medication (ASM) prescriptions and neurodevelopmental comorbidities. We used a mixed effects Poisson regression model to determine temporal trends of SeLECTS incidence and its association with socioeconomic deprivation.
Results:
We identified 6,732 children with epilepsy, 186 (3%) with SeLECTS. In 2017, epilepsy and SeLECTS prevalence was 0.55% and 0.02% respectively, with corresponding crude incidence of 51/100,000/year and 1/100,000/year. Twenty one percent of children with epilepsy and 11% of children with SeLECTS had a comorbid neurodevelopmental disorder. The incidence of epilepsy in children was associated with deprivation with an adjusted incidence rate ratio (AIRR) of 1.4 (95%CI 1.2-1.6) in the most compared with least deprived quintile. For children with SeLECTS, corresponding AIRR was 1.4 (95% CI 0.5–2.0). Choice of initial ASM for children with SeLECTS did not change during the study period with sodium valproate and carbamazepine being prescribed in the vast majority ( >95%).
Conclusions:
In this Welsh cohort, there was a lower than previously reported incidence of SeLECTS. This may be due to under-recording. A high proportion of children with SeLECTS have comorbid neurodevelopmental disorders. There is some evidence that, unlike all childhood epilepsies, there was no significant association between SeLECTS and deprivation. Despite concerns about valproate, up until 2017, it remained a preferred initial ASM for SeLECTS in this cohort.
Funding:
The Waterloo Foundation
Epidemiology