Epilepsy Self-management for Depression: Aggregate Managing Epilepsy Well Network Findings
Abstract number :
1.222
Submission category :
4. Clinical Epilepsy / 4C. Clinical Treatments
Year :
2019
Submission ID :
2421217
Source :
www.aesnet.org
Presentation date :
12/7/2019 6:00:00 PM
Published date :
Nov 25, 2019, 12:14 PM
Authors :
Martha Sajatovic, Case Western Reserve University; Erika K. Johnson, University of Washington; Robert T. Fraser, University of Washington; Kristin A. Cassidy, Case Western Reserve University School of Medicine; Honyan Liu, Case Western Reserve University
Rationale: To assess depressive symptom outcomes in a pooled sample of epilepsy self-management randomized controlled trials (RCTs) from the Managing Epilepsy Well (MEW) Network integrated research database (MEW DB). Methods: Five prospective RCTs involving 453 patients with epilepsy compared self-management (n=232) outcomes vs. treatment as usual or wait-list control (n=221). Depression was assessed with the 9-item Patient Health Questionnaire (PHQ-9). Other variables included age, gender, race, ethnicity, education, income, marital status, seizure frequency and quality of life. Follow-up assessments were collapsed into two visits conducted post RCT baseline. Results: Sample mean age was 43.5 (SD 12.6), nearly 2/3 women and nearly 1/3 African-American. Baseline demographic and clinical characteristics were mostly similar between self-management vs. controls. At follow-up the self-management group had a significantly greater reduction in depression compared to controls at visit 2 (p <.0001) and visit 3 (p=.0002). Quality of life also significantly improved in self-management at visit 2 (p =.001) and visit 3 (p=.005). Conclusions: Aggregate analysis of five RCTs from the MEW DB found depressive symptom severity and quality of life significantly improved in individuals randomized to self-management vs. controls. Evidence-based epilepsy self-management programs should be made more broadly available in neurology practices. Funding: Centers for Disease Control and Prevention (CDC)
Clinical Epilepsy