EVALUATION AND COMPARISON OF SEIZURE CONTROL DURING ESCALATION OF LAMOTRIGINE, VALPROIC ACID, CARBAMAZEPINE AND PHENYTOIN AS INITIAL MONOTHERAPY IN PATIENTS WITH EPILEPSY
Abstract number :
2.183
Submission category :
Year :
2002
Submission ID :
886
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Victor Biton, David Blum, Dawn Groenke, Anne Hammer, John Messenheimer. Arkansas Epilepsy Program, Little Rock, AR; Epilepsy Clinical Development and Medical Affairs, GlaxoSmithKline, Research Triangle Park, NC
Objective: Assess and compare the efficacy of several antiepileptic drugs (AEDs) during escalation of initial monotherapy.
The use of lamotrigine (LTG) requires initiation of low doses and careful titration. While the favorable efficacy and tolerability of LTG at maintenance doses are well established, there is a need to assess them and compare with other AEDs during the titration period.
METHODS: Seizure data from the escalation phase of four blinded and well-controlled studies of AED initial monotherapy [including lamotrigine (LTG), valproic acid (VPA), carbamazepine (CBZ), and phenytoin (PHT)] were aggregated. AEDs were initiated over a 6-8 week period. Patients studied were experiencing partial or generalized seizures or both.
RESULTS: [table1]ANOVA showed no significant difference between LTG and other AEDs.
CONCLUSIONS: Lamotrigine efficacy during initial monotherapy dose escalation is comparable to the efficacy during initial monotherapy dose escalation of VPA, CBZ and PHT.
[Supported by: GlaxoSmithKline Research and Development]; (Disclosure: Salary - Co-authors are employees of GlaxoSmithKline, Grant - Dr. Biton received a research grant for conduct of this study from GlaxoSmithKline, Consulting - yes, Honoraria - yes)