Abstracts

Rationale: Focal seizures could be triggered by the hyperglycemia. However the reasons for the development of focal seizures in the hyperglycemic patients are still unclear. Herein, we investigated the seizure types in the hyperglycemic patients and describe the factors affecting the semiology.Methods: We retrospectively identified patients with hyperglycemia and seizure who were admitted or consulted to the department of neurology at our institution between January, 2013 and January, 2015, and investigated semiology, brain images, and electroencephalography (EEG) findings. The patients with previous seizure attack and unwitnessed seizure events were excluded.Results: Total ten patients were selected. Mean age was 59.6 years. Male/female ratio was 6/4. Focal seizures were identified in seven patients (70%: group A, others: group B). In the group A patients, four of seven patients (57.1%) had structural brain lesions. The semiology and EEG features were corresponded with the underlying brain lesions in these patients. None of the group B patients had brain cortical lesions. Blood glucose levels were lower in the patients with brain lesions (337.3 mg/dl versus 461.8 mg/dl). Other factors including age and sex did not show statistical differences.Conclusions: Focal seizures are frequent in the hyperglycemic patients. The patients with underlying brain lesion might be more vulnerable to the hyperglycemic stress than without. Further large studies are required to understand the characteristics of seizure in the hyperglycemia.