Factors Underlying Scalp Interictal Epileptiform Discharges (IED) in Intractable Frontal Lobe Epilepsy.
Abstract number :
1.081
Submission category :
Year :
2001
Submission ID :
272
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
L. Vadlamudi, MBBS, FRACGP, FRACP, Neurology, Mayo Clinic, Rochester, MN; E.L. So, MD, Neurology, Mayo Clinic, Rochester, MN; G.A. Worrell, PhD, MD, Neurology, Mayo Clinic, Rochester, MN; G.D. Cascino, MD, Neurology, Mayo Clinic, Rochester, MN; T.G. Lesni
RATIONALE: Certain risk factors for developing epilepsy may influence the presence of IED in intractable frontal lobe epilepsy. This study determines whether epilepsy risk factors are associated with the presence and distribution of IED in patients with intractable frontal lobe epilepsy.
METHODS: We retrospectively studied 53 intractable frontal lobe epilepsy patients who underwent epilepsy surgery between 1987 and 1999. All had excellent surgical outcome (seizure free or rare simple partial seizures). Results of scalp EEG recordings were reviewed for the presence and distribution of IED, as well as for frontal slowing. Risk factors assessed included congenital abnormalities, perinatal distress, febrile seizures, neonatal seizures, intracranial infection, brain trauma, stroke, family history of epileptic seizures, presence of secondary generalized seizures, & history of status epilepticus. Fisher[ssquote]s Exact Test was used to determine statistically significant associations between IED and risk factors, and odds ratios (OR) were also calculated.
RESULTS: Patients with family history of seizures were less likely to have frontal IED (p=0.03; OR=0.17), and less likely to have lesional epilepsy (p=0.04; OR=0.19). However, the proportion of patients with frontal IED was not significantly different between lesional (n=37) & non-lesional (n=16) patients (p=1.00). There was a tendency for patients with a history of status epilepticus to have generalized or extra-frontal IED (p=0.06; OR=8.00).
CONCLUSIONS: With the exception of family history of seizures, scalp IED in patients with intractable frontal lobe epilepsy are not associated with traditional epilepsy risk factors. There is a tendency for patients with a history of status epilepticus to have generalized IED or IED that are outside the frontal region.
Support: Mayo Foundation for Medical Research and Education