Four-dimensional Map of the Error Detection Network
Abstract number :
1.023
Submission category :
1. Basic Mechanisms / 1C. Electrophysiology/High frequency oscillations
Year :
2022
Submission ID :
2203926
Source :
www.aesnet.org
Presentation date :
12/3/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:22 AM
Authors :
Yongje Jeon, – Yokohama City University; Riyo Ueda, MD, PhD – Wayne State University; Yoshio Shiimoto, Medical student – Yokohama City University; Kazuki Sakakura, MD – Wayne State University; Yu Kitazawa, MD, PhD – Wayne State University; Masaki Sonoda, MD, PhD – Assistant Professor, Yokohama City University; Eishi Asano, MD, PhD, MS – Professor, Wayne State University
Rationale: Humans detect their erroneous actions within hundreds of milliseconds, and such rapid error detection is essential in our daily life. The present study explored the spatiotemporal dynamics of neural modulations elicited by incorrect responses during a one-back task.
Methods: During intracranial EEG monitoring at the bedsides, eight right-handed patients with drug-resistant focal epilepsy played a Lumosity cognitive training game, ‘Speed Match’ (Figure 1). This game presented five different symbols in random order, and each patient needed to tap a Yes button if an incoming symbol matched the previous one but a No if it did not. Each patient played five one-minute sessions. Time-frequency analysis quantified the amplitude modulation of high-gamma activity (70-110 Hz) at given electrodes and each 10-ms time bin. Group-level animation atlases visualized the spatiotemporal dynamics of high-gamma modulations during [a] correct and [b] incorrect responses immediately after a correct response (i.e., [a] ‘Correct→Correct’ trials and [b] ‘Correct→Incorrect’ trials).
Results: The number of trials ranged from 111 to 227 per patient (mean: 167). The mean number of ‘Correct→Correct’ trials was 132 per patient, whereas that of ‘Correct→Incorrect’ trials was 15. Incorrect response-specific high-gamma augmentation involved the right posterior fusiform gyrus at 300-500 ms post-response onset, right superior temporal gyrus at 340-500 ms, and right posterior frontal regions at 370-500 ms (Figure 2).
Conclusions: The present study provided preliminary evidence that a large-scale network in the right temporal and frontal lobes may support error detection in a visuospatial domain.
Funding: NIH grant NS64033 (to E. Asano)
Basic Mechanisms