Frontal, but Not the Same: Cognitive System Reorganization in Frontal Lobe and Juvenile Myoclonic Epilepsy
Abstract number :
2.192
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2022
Submission ID :
2204484
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:25 AM
Authors :
Lorenzo Caciagli, MD PhD – University of Pennsylvania; Casey Paquola, PhD – Forschungszentrum Jülich; Britta Wandschneider, MD PhD – Queen Square Institute of Neurology – University College London; Xiaosong He, PhD – University of Pennsylvania; Christian Vollmar, MD PhD – Ludwig-Maximilians-Universität; Maria Centeno, MD PhD – Hospital Clínic de Barcelona; Panagiotis Fotiadis, BS – University of Pennsylvania; Karin Trimmel, MD PhD – Medical University of Vienna; Meneka Sidhu, MBBS PhD – Queen Square Institute of Neurology – University College London; Pamela Thompson, PhD – Queen Square Institute of Neurology – University College London; Sallie Baxendale, PhD – Queen Square Institute of Neurology – University College London; John Duncan, DM FRCP – Queen Square Institute of Neurology – University College London; Boris Bernhardt, PhD – McConnell Brain Imaging Center – McGill University; Matthias Koepp, MD PhD FRCP – Queen Square Institute of Neurology – University College London; Dani Bassett, PhD – Department of Bioengineering – University of Pennsylvania
This abstract has been invited to present during the Neuroimaging platform session
Rationale: Frontal lobe epilepsy (FLE) and juvenile myoclonic epilepsy (JME) are characterized by frontal ictogenesis, and are regarded as behaviorally and cognitively similar. Whether the underlying functional network architecture is comparable, however, remains unexplored. Prior work reported similar working memory difficulties and related frontal hypometabolism. We previously described large-scale disorganization of task-related recruitment in FLE, and cognition-related motor hyperactivity in JME. Here, we directly compare FLE and JME to establish commonalities and differences in cognitive profiles, and capture the spectrum of functional abnormalities that underlie frontal ictogenesis.
Methods: We studied 147 individuals: 58 with FLE [age, mean (SD): 33.7 (10.5) years; 29 females; 30/25/3 left-sided/right-sided/non-lateralized; 32 non-lesional], 37 with JME [31.9 (10.4) years, 20 females], and 52 controls [34.1 (10.4) years; 30 females], who all underwent an extensive neuropsychological test battery and 3 fMRI tasks probing verbal fluency, verbal working memory, and visual working memory. Groups were comparable for age, sex, and handedness. People with FLE had an earlier age at seizure onset (~3.5 years earlier; p< 0.001) and a higher anti-seizure medication load [median (IQR), 3 (1) vs. 2 (1), p< 0.001) than those with JME, but comparable disease duration. We analyzed imaging data with standard SPM12 pipelines. We compared groups with ANCOVA and full-factorial SPM models for cognitive and imaging data, respectively, followed by 2-sample t-tests; all analyses employed age and sex as covariates. Sensitivity analyses addressed the effects of age at onset and drug load.
Neuro Imaging