Fronto-Parietal Network Functional Connectivity, Depression and Quality of Life in People with Epilepsy or Psychogenic Non-Epileptic Seizures (PNES)
Abstract number :
3.252
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2021
Submission ID :
1826168
Source :
www.aesnet.org
Presentation date :
12/6/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:52 AM
Authors :
Rodolphe Nenert, PhD - University of Alabama at Birmingham; Jane Allendorfer - University of Alabama at Birmingham; Adam Goodman - University of Alabama at Birmingham; Pranav Kakulamarri - University of Alabama at Birmingham; Stephen Correia - Brown University, Providence VAMC, Providence, RI; Noah Philip - Brown University, Providence VAMC, Providence, RI; W. Curt LaFrance - Brown University, Providence VAMC, Providence, RI; Jerzy Szaflarski - University of Alabama at Birmingham
Rationale: Traumatic brain injury (TBI) often precedes the onset of epileptic seizures (ES) or PNES; depression is a common comorbidity in both. Quality of life (QOL) in people with PNES have been shown to be worse than in those with ES. Lin et al. (2019) found that the negative correlation between depression severity and QOL was mediated by fronto-parietal network resting state functional connectivity (rs-FC). In this study, we investigated whether similar relationships exist in people with TBI with and without ES or PNES.
Methods: Adults with TBI (TBI-only; n=60; 28 male), ES after TBI (TBI+ES; n=21; 10 male), or PNES after TBI (TBI+PNES; n=56; 14 male) were recruited. Subjects completed the Beck Depression Inventory II (BDI-II) and 31-item QOL in Epilepsy (QOLIE-31) assessments and underwent resting state functional MRI. Images were processed using SPM12 software running in MatLab. Z-scores representing strength of rs-FC between each of the fronto-parietal network regions were extracted: inferior frontal gyrus (IFG), middle frontal gyrus (MFG), supramarginal gyrus (SG), inferior parietal lobule (IPL), superior parietal lobule (SPL), paracentral lobule (PL), and supplementary motor area (SMA). Pearson’s correlations were performed to examine relationships between depression symptom severity (BDI-II), QOLIE-31 overall T-score, QOL subscale T-score, and rs-FC z-scores (p< 0.05, FDR corrected).
Neuro Imaging