Generalized features in Focal Epilepsy
Abstract number :
937
Submission category :
4. Clinical Epilepsy / 4B. Clinical Diagnosis
Year :
2020
Submission ID :
2423270
Source :
www.aesnet.org
Presentation date :
12/7/2020 1:26:24 PM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
René Andrade Machado, Detroit Medical Center; Mona Elsayed - Wayne State University; Rohit Marawar - Wayne State University, Detroit, MI, USA; Deepti Zutshi - Wayne State University; Maysaa Basha - Wayne State University;;
Rationale:
Generalized interictal and ictal features in adult patients with focal epilepsy are poorly characterized. The aim of the present study is to assess electrographic (EEG) characteristics of patients with focal epilepsy and generalized epileptiform discharges, their frequency and impact on clinical features.
Method:
We retrospectively reviewed consecutive patients with focal epilepsy admitted to the Epilepsy Monitoring Unit for diagnostic and assessment over the past 12 months. Video-EEG monitoring was performed using 21 scalp electrodes according to the International10/20 system. In some patients, additional sphenoidal electrodes were inserted. Diagnosis of focal epilepsy is based on seizure semiology, interictal and ictal EEG recordings as well as neuroimaging. Focal seizures with or without secondary generalization were analyzed. Inclusion criteria include a minimum of one focal seizure with or without secondary generalization during the monitoring. If the patient had several seizures, only the first three seizures were included in the study. Generalized epileptiform discharges (GED) and generalized seizures were investigated. All clinical and laboratory findings of both groups were compared using parametric statistical analysis.
Results:
A total of 35 patients were included. GED were present in 7 (21; 3 males) patients; 6 out of 7 also had generalized seizures. Two patients (6%) had focal and generalized seizures in the same admission. Of 85 seizures captured, 16 (19%) had generalized ictal onset. The most common epilepsies with GED were fronto-temporal epilepsies. Five out of 6 patients with GED also had focal discharges; one patient only had GED. We did not find any association among gender and seizures duration and the presence of generalized seizures.
Conclusion:
The presence of generalized seizures and epileptiform discharges is not uncommon in adults with focal epilepsy. Focal and generalized seizures can coexist, and generalized features are most commonly seen in patient with fronto-temporal epilepsy.
Funding:
:None
Clinical Epilepsy