Generator replacement with cardiac-based VNS device in children with drug-resistant epilepsy
Abstract number :
272
Submission category :
3. Neurophysiology / 3E. Brain Stimulation
Year :
2020
Submission ID :
2422618
Source :
www.aesnet.org
Presentation date :
12/6/2020 12:00:00 PM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
Aristides Hadjinicolaou, The Hospital for Sick Children; Puneet Jain - The Hospital for Sick Children; Ravindra Arya - Cincinnati Children's Hospital Medical Center; Celie Roth - Cincinnati Children's Hospital Medical Center; Robyn Whitney - The Hospital
Rationale:
This study evaluated the seizure outcomes in children with drug-resistant epilepsy (DRE), having a pre-existing VNS device, after generator replacement with cardiac-based VNS device.
Method:
This retrospective study enrolled 30 children with DRE form 2 centres with an existing VNS device nearing end-of-service who underwent generator replacement with cardiac-based VNS device and had at least 1 year follow up. Seizure outcomes and adverse effects were studied.
Results:
The mean age at insertion of cardiac-based VNS device was 15.03 years. 26.7% patients showed at least one class improvement at last follow up (mean 2.08 years) and half of the patients maintained their McHugh seizure-outcome class. Thirty-six percent of patients had > 50% seizure reduction at last follow up. Ten patients reported improvement in ictal severity. Most of the patients tolerated the replacement well.
Conclusion:
Nearly one-third of patients with DRE showed additional improvement after replacement with cardiac based VNS device. Half of the patients maintained their seizure control.
Funding:
:N/A
Neurophysiology