Hippocampal Subfield Segmentation and Associations with Memory Outcomes in TLE
Abstract number :
2.455
Submission category :
5. Neuro Imaging / 5A. Structural Imaging
Year :
2022
Submission ID :
2232965
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:29 AM
Authors :
Shahryar Pourkalhor, BSc Student – University of Alberta; Luciana Ramalho Pimentel-Silva, PhD – University of Alberta; Pablo Antonio Stack Sanchez, MSc – University of Alberta; Jordan Urlacher, PhD – University of Alberta; Bradley Karat, BSc – University of Western Ontario; Sarah Treit, PhD – University of Alberta; Ali Khan, PhD – University of Western Ontario; Christian Beaulieu, PhD – University of Alberta; Donald Gross, MD – University of Alberta
This is a Late Breaking abstract
Rationale: Temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) is the most common form of drug-resistant epilepsy. Memory impairment is a frequent comorbidity in patients with TLE, however, the relationship between hippocampal subfield pathology and memory deficits remains unclear [1]. Here we aimed to evaluate the correlations between hippocampal subfield volume loss, and verbal and nonverbal memory deficits using high resolution diffusion-weighted imaging (DWI).
Methods: Eighteen TLE patients (40±15 standard deviation [18-66] years, 15 right-handed [83%], 10 females [55%]) were included in the study with all subjects having MRI and cognitive assessments. 1-millimeter isotropic DWI was acquired aligned with the axial plane of the hippocampus using a 3T Siemens Prisma MRI scanner (b=500 s/mm2, 10 directions, 10 averages, and 20 slices, ~5min scan time) [2]. MRI images were corrected for Gibbs ringing (optimized for partial Fourier), eddy currents, and motion artifacts using Matlab and MRtrix. Automatic subfield segmentation was then performed using Hippunfold, a deep learning-based software (Figure 1) [3]. The Rey Auditory Verbal Learning Test (RAVLT) was used for immediate and delayed verbal memory and Rey Complex Figure Test and Recognition Trial (RCFT) for delayed non-verbal recall. Partial correlation analysis was performed using SPSS (IBM, version 26) to test the associations between left and right hippocampal subfield volumes and age-normalized cognitive scores while controlling for years of education. P< 0.05 was set as significant. Multiple comparisons were corrected for false discovery rate using the Benjamini-Hochberg method.
Neuro Imaging