Abstracts

Rationale: Although GIE is the kind of epilepsy that most respects cognitive domains, there are various studies in the literature that warn about subtle deficits in these patients that fundamentally affect executive functions and impulsivity that sometimes affect their social integration. The objective of our study is to delineate a differential neuropsychological profile in these patients with special attention to frontal cognitive areas and executive functions. Methods: Retrospective descriptive observational study of a group of 24 patients with EGI versus a control group of 20 subjects. A battery of neuropsychological tests was applied in order to analize the following: short and long term verbal and visual memory, selective and divided attention, inhibition, processing speed, verbal and visual work memory, planning, cognitive flexibility, abstraction ability, fluency, visuospatial skill and emotional scales that collected data on the subjects´ depressed anxious state and apathy. Results: Significant differences were found in short and long term memory for both verbal (p < 0.006) and visual (p < 0.005), learning (p < 0.002), selective and alternating attention (p < 0.009), visual working memory P < 0.001), motor programming, cognitive flexibility (p < 0.004), fluency (p> 0.001), processing speed (p < 0.018), alternation (p < 0.001), visuospatial skill (p < 0.001) Abstraction (p < 0.001). Conclusions: The results obtained show a homogeneous cognitive profile compatible with altered functioning at the level of the dorsolateral prefrontal cortex. These findings may explain the behavioral and social changes described in these patients. Funding: Nothing to declare.