How does having a first degree relative with epilepsy affect outcome after temporal lobe surgery?
Abstract number :
1.320
Submission category :
9. Surgery / 9A. Adult
Year :
2017
Submission ID :
339991
Source :
www.aesnet.org
Presentation date :
12/2/2017 5:02:24 PM
Published date :
Nov 20, 2017, 11:02 AM
Authors :
Kelli E. Farmer, Vanderbilt University Medical Center; Kevin F. Haas, Vanderbilt University Medical Center; Amir M. Arain, Vanderbilt University Medical Center; Hasan H. Sonmezturk, Vanderbilt University Medical Center; Amar B. Bhatt, Vanderbilt Universit
Rationale: There is a concern that a genetic predisposition may negatively affect epilepsy surgery outcome on the grounds that genetic predisposition may indicate a more diffuse seizure tendency. Methods: Using an epilepsy surgery database we compared seizure outcome two years after temporal lobe epilepsy surgery (selective amygdalohippocampectomy, temporal lobectomy, or lesionectomy) in two groups of patients: a group who had first degree relatives with epilepsy and a group with no family history of epilepsy. Surgical outcome was based on the Engel outcome classification. We considered Engel class 1 and 2 outcomes as favorable. Results: Among 156 patients with no family history of epilepsy, 111 (71%) had Engel class 1 outcome and 24 (15%) had Engel class 2 outcome, with an overall favorable outcome of 86%. The remaining 21 patients had class 3 (15 patients) or class 4 (6 patients) outcome. Among 39 patients with first degree relatives with epilepsy, 25 (64%) had Engel class 1 outcome and 8 (21%) had Engel class 2 outcome, for an overall favorable outcome of 85%. The remaining 6 patients had class 3 (4 patients) and class 4 (2 patients) outcome. Conclusions: Having a first degree relative with epilepsy does not influence outcome after temporal lobe epilepsy surgery. Funding: none
Surgery