Abstracts

Rationale: The number of children with IS secondary to perinatal stroke is limited in many cohort studies due to the small sample size of this category. Moreover, less studies reported the outcome of children with isolated IS due to perinatal stroke post-hemispherotomy (Taussig D, et al. Hemispherotomy for isolated infantile spasms following perinatal ischemic stroke. Eur J Paediatr Neurol. 2015;19(5):597-602. Krynauw RA. Infantile hemiplegia treated by removing one cerebral hemisphere. J Neurol Neurosurg Psychiatry.1950;13(4):243-67). The aim of this study is to report the seizure and developmental outcome of subjects with infantile spasms (IS) secondary to perinatal stroke and the effect of surgical intervention (hemispherotomy) on clinical outcomes.  Methods: We retrospectively collected seizure and developmental outcome data of eight infants who diagnosed with IS and perinatal stroke between 2006-2015 at the Hospital for Sick Children in Toronto, Canada. We compare the clinical and developmental outcome between surgical and non-surgical groups.  Results: All children in both the surgical and non-surgical groups had developmental delay and cerebral palsy (Table 1). All three children with hemispherotomy (3/8) had an early surgical intervention (mean age: 12.6, range 9 - 18 months) and were seizure-free with post-operative follow up until age of 2 to 6 years. There was no significant difference in clinical and developmental outcomes between children with early versus late diagnosis of perinatal stroke.  Conclusions: Among surgical candidate IS children with perinatal strokes, the study supports an early surgical intervention for better developmental outcome and seizure control. More studies with larger sample size are needed to assess the outcome of surgical intervention among symptomatic IS group.  Funding: No funding