Long-Term Memory Development of Patients with Refractory Epilepsy after Temporal Lobe Surgery
Abstract number :
1.219
Submission category :
Neuropsychology/Language Cognition-Adult
Year :
2006
Submission ID :
6353
Source :
www.aesnet.org
Presentation date :
12/1/2006 12:00:00 AM
Published date :
Nov 30, 2006, 06:00 AM
Authors :
1Ivana Tyrlikova, 1Zuzana Fanfrdlova, 1Milan Brazdil, 1Robert Kuba, 1Ivan Rektor, 2Zdenek Novak, and 2Jan Chrastina
Patients with epilepsy may be at risk from memory decline after temporal lobe resection. We focused our research on evaluating particular factors as possible risk predictors of further memory development., A group of 23 patients (15 males and 8 females; aged 15 to 55 years) with refractory temporal lobe epilepsy undertook surgery. The patients were assessed according to Engel classification annually for five years.
An amygdalo-hippocampectomy - 8 patients; the anterior medial temporal resection - 10 patients; a tailored lesionectomy - 5 patients. The Wechsler Memory test III was used to assess memory repeatedly during five years (before the surgery; 1 [ndash] 2 years and 5 years after the surgery)., We split the sample to five consistent groups according to results of a hierarchical cluster analysis.
The means of the first assessment of MQ in groups I, II and III belong to different ranges (a below-average, an average and an above-average range). All the three groups are consistent in low changes in the interval between pre-surgery and one-year post-surgery measurement (the first period) and decrease of MQ in the period between one year and five years after surgery (the second period).
The means MQ of the groups IV and V, which start at average and above average ranges respectively, decrease in the first period and then increase in the second period again.[figure1]We have evaluated predictors of both values of MQ and a profile of memory development during five years after the surgery.
We did not find out any relation to the MQ values.
We have united groups I, II and III (profile 1) and groups IV, V (profile 2) into two groups.
We discovered an effect when we compared the two profiles of memory development. There were no female patients in profile 2 (42% in profile 1). There were 33,3% of patients with mesiotemporal sclerosis(MTS) and 66,7% other structural lesions in profile 2, while profile 1 consisted of 78,6% of MTS patients and 21,4% of patients with other structural lesions.
There are 16,7% of patients who undertook hippocampectomy in profile 2, compared to 50% of these patients in profile 1.
We measured the Ia outcome according to Engel[apos]s classification, achieved during the whole 5-year period. 66,7% of patients in profile 2 achieved the Ia level continuously (only 21,4% in profile 1)., The results support assumption that MTS etiology, limited resections and worse long-term outcomes predict worse memory development.,
Behavior/Neuropsychology