Low Frequency Stimulation in Patients with Responsive Neurostimulation
Abstract number :
1.162
Submission category :
3. Neurophysiology / 3E. Brain Stimulation
Year :
2021
Submission ID :
1826664
Source :
www.aesnet.org
Presentation date :
12/4/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:55 AM
Authors :
Juan Luis Alcala-Zermeno, MD - Mayo Clinic, Rochester, MN; Melinda Marthaler - NeuroPace Inc; Cindy Nelson, R EEG T - Neurology - Mayo Clinic, Rochester, MN; Gamaleldin Osman, M.B.B.Ch. - Neurology - Mayo Clinic, Rochester, MN; Richard Marsh, MD - Neurologic Surgery - Mayo Clinic, Rochester, MN; Jamie Van Gompel, MD - Neurologic Surgery - Mayo Clinic, Rochester, MN; Kai Miller, MD, PhD - Neurologic Surgery - Mayo Clinic, Rochester, MN; Nicholas Gregg, MD - Neurology - Mayo Clinic, Rochester, MN; Gregory Worrell, MD, PhD - Neurology - Mayo Clinic, Rochester, MN; Brian Lundstrom, MD, PhD - Neurology - Mayo Clinic, Rochester, MN
Rationale: Chronic intracranial neurostimulation modalities require programming of stimulation frequency, amplitude, pulse width, and duration per method of stimulation. Responsive neurostimulation (RNS) and anterior thalamic nucleus deep brain stimulation (DBS-ANT) are both FDA-approved invasive brain stimulation approaches for the treatment of medication-resistant focal epilepsy. For RNS and DBS-ANT, frequency of stimulation (Fq) is typically ≥100Hz, which is consistent with data from pivotal trials1,2, and here termed high frequency stimulation (HFS). Lower stimulation frequencies (< 100Hz) have been used in epilepsy for DBS of centromedian thalamus and cerebellum as well as cortical stimulation of hippocampus and/or other cortical areas in chronic subthreshold stimulation (CSS)
Neurophysiology