Microstructural Differences of MRI in Children with Developmental Delay
Abstract number :
1.248
Submission category :
5. Neuro Imaging / 5A. Structural Imaging
Year :
2021
Submission ID :
1825983
Source :
www.aesnet.org
Presentation date :
12/9/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:51 AM
Authors :
Jung Hye Byeon, MD PhD - Korea University; Kyu Hyun Park – Department of Pediatrics – Korea University; Young Kyu Shim – Department of Pediatrics – Korea University; Baik-Lin Eun – Department of Pediatrics – Korea University;
Rationale: Premature birth can induce many neurological problems such as developmental delay or epilepsy. This study aimed to examine the brain microstructural differences in children with developmental delay and compare with normal developed children.
Methods: MRI was used to evaluate corrected 18±3 months old aged 41 patients with developmental delay without recognizable abnormality in neonatal imaging and 23 matched normal developed children. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) were analyzed separately to identify regional brain differences. Delayed development was defined under 2 standard deviation by SELSI, BSID II or III.
Results: Children with developmental delay demonstrated significantly low gray matter concentration in major temporal lobe and limbic systems, including both cingulate cortex, hippocampus, and amygdala. And in TBSS analysis, which subject at near 18 month of corrected age, developmental delay children had significant changes in DTI values, especially in the superior longitudinal fasciculus (SLF) and corona radiata (CR).
Conclusions: Main function of limbic system is emotion, cognition and memory. This finding suggests that low concentration of gray matter correlate with cognitive impairments in children with developmental delay. Increased AD, RD, and MD values suggest axonal damages in the SLF and CR. It is suggested that VBM and TBSS analysis could be an additional tool for take further information about development in which children before no significant abnormality in traditional MRI.
Funding: Please list any funding that was received in support of this abstract.: This work was supported by National Research Foundation of Korea grant(NRF-2019R1G1A1100508).
Neuro Imaging